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  • Title: Amino-acid-enzyme activities in brown and white adipose tissues and in the liver of cafeteria rats. Effects of 24 hours starving.
    Author: Serra F, Bonet L, Palou A.
    Journal: Arch Int Physiol Biochim; 1987 Nov; 95(4):263-8. PubMed ID: 2453168.
    Abstract:
    Moderate obesity (17% excess body weight) was induced in female rats by offering a "cafeteria" diet during 82 days. The adaptive changes in five amino-acid-metabolism enzymes were determined in liver and white- and brown adipose tissues by comparison with chow fed controls both in the fed and 24-h starved states. Plasma urea levels were lower in the obese and the changes in enzymatic activities pointed to a lower rate of amino-acid metabolism in our dietary obesity group. The levels of activity of amino-acid-metabolism enzymes in brown adipose tissue were higher than in white adipose tissue and in most cases comparable to that of liver. The importance of amino acids as a fuel source in brown adipose tissue thermogenesis cannot be ruled out.
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