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  • Title: Reversible electrical breakdown of lipid bilayers: formation and evolution of pores.
    Author: Glaser RW, Leikin SL, Chernomordik LV, Pastushenko VF, Sokirko AI.
    Journal: Biochim Biophys Acta; 1988 May 24; 940(2):275-87. PubMed ID: 2453213.
    Abstract:
    The mechanism of reversible electric breakdown of lipid membranes is studied. The following stages of the process of pore development are substantiated. Hydrophobic pores are formed in the lipid bilayer by spontaneous fluctuations. If these water-filled defects extend to a radius of 0.3 to 0.5 nm, a hydrophilic pore is formed by reorientation of the lipid molecules. This process is favoured by a potential difference across the membrane. The conductivity of the pores depends on membrane voltage, and the type of this dependence changes with the radius of the pore. Hydrophilic pores of an effective radius of 0.6 up to more than 1 nm are formed, which account for the membrane conductivity increase observed. The characteristic times of changes in average radius and number of pores during the voltage pulse and after it are investigated.
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