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  • Title: Antiproliferative and antiviral activity of three libraries of adamantane derivatives.
    Author: Basarić N, Sohora M, Cindro N, Mlinarić-Majerski K, De Clercq E, Balzarini J.
    Journal: Arch Pharm (Weinheim); 2014 May; 347(5):334-40. PubMed ID: 24532384.
    Abstract:
    Three libraries of adamantane derivatives were synthesized and evaluated for antiviral and antiproliferative activities against a broad variety of DNA and RNA viruses. Whereas none of the compounds exhibit antiviral activity at subtoxic concentrations, antiproliferative activity was found against murine leukemia cells (L1210), human T-lymphocyte cells (CEM), and cervix carcinoma cells (HeLa) for 4, 8, and 10.
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