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  • Title: Quantitative analysis of Chiari-like malformation and syringomyelia in the Griffon Bruxellois dog.
    Author: Knowler SP, McFadyen AK, Freeman C, Kent M, Platt SR, Kibar Z, Rusbridge C.
    Journal: PLoS One; 2014; 9(2):e88120. PubMed ID: 24533070.
    Abstract:
    This study aimed to develop a system of quantitative analysis of canine Chiari-like malformation and syringomyelia on variable quality MRI. We made a series of measurements from magnetic resonance DICOM images from Griffon Bruxellois dogs with and without Chiari-like malformation and syringomyelia and identified several significant variables. We found that in the Griffon Bruxellois dog, Chiari-like malformation is characterized by an apparent shortening of the entire cranial base and possibly by increased proximity of the atlas to the occiput. As a compensatory change, there appears to be an increased height of the rostral cranial cavity with lengthening of the dorsal cranial vault and considerable reorganization of the brain parenchyma including ventral deviation of the olfactory bulbs and rostral invagination of the cerebellum under the occipital lobes.
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