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  • Title: Translocated c-myc genes produce chimeric transcripts containing antisense sequences of the immunoglobulin heavy chain locus in mouse plasmacytomas.
    Author: Julius MA, Street AJ, Fahrlander PD, Yang JQ, Eisenman RN, Marcu KB.
    Journal: Oncogene; 1988 May; 2(5):469-76. PubMed ID: 2453828.
    Abstract:
    Immunoglobulin heavy chain gene antisense transcripts contribute to the expression of translocated c-myc genes in several murine plasma cell tumors. These novel, chimeric transcripts comprise 5-50% of steady-state c-myc mRNA. Two transcripts isolated as cDNA clones use the normal splice donor and acceptor sites within the c-myc first intron. Another cDNA clone has the potential for encoding two types of c-myc proteins. The significance of immunoglobulin heavy chain gene antisense transcripts and transcriptional competence of the immunoglobulin heavy chain locus for c-myc expression is discussed.
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