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  • Title: Proteolytic degradation of desmosomes in plantar stratum corneum leads to cell dissociation in vitro.
    Author: Egelrud T, Hofer PA, Lundström A.
    Journal: Acta Derm Venereol; 1988; 68(2):93-7. PubMed ID: 2454007.
    Abstract:
    Pieces of plantar stratum corneum were incubated with trypsin. This resulted in cell dissociation. The only observable ultrastructural change caused by trypsin was a degradation of desmosomal plates between dissociating cells. This suggests that desmosomes are of primary importance in plantar stratum corneum cell adhesion.
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