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  • Title: Vascular effects of neuropeptides on nasal mucosa.
    Author: Ichimura K, Mineda H, Seki A.
    Journal: Ann Otol Rhinol Laryngol; 1988; 97(3 Pt 1):289-93. PubMed ID: 2454064.
    Abstract:
    We used dog nasal blood vessels and an in vitro muscle tension-detecting technique to examine the vascular effects of several neuropeptides: vasoactive intestinal polypeptide, substance P, neurotensin, somatostatin, and neuropeptide Y (NPY). Electrically induced vasoconstriction was inhibited by every peptide except neurotensin, which enhanced this response. Every preparation treated with somatostatin, and one tissue treated with NPY, showed an enhanced noradrenaline-induced contraction. Only NPY caused a tissue contraction. Preparations precontracted by methoxamine were relaxed by every peptide. These results indicate that all peptides examined have marked but varied vasoactivities.
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