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  • Title: Nifedipine and BAY K inhibit contraction independently from their action on calcium channels.
    Author: Jacquemond V, Rougier O.
    Journal: Biochem Biophys Res Commun; 1988 May 16; 152(3):1002-7. PubMed ID: 2454099.
    Abstract:
    Voltage-clamp experiments were performed on twitch skeletal muscle fibres in a double sucrose-gap device in order to investigate the effect of 1,4-dihydropyridines (DHP) on excitation-contraction coupling during 50 ms step depolarizations. External solution used was free of permeant anions and contained only Ca++ as permeant cation. It is shown that in these conditions Nifedipine (a Ca++ channel antagonist) and BAY K 8644 (a Ca++ channel agonist) inhibit contraction in a way independent of their action on the gating of tubular calcium channels. These results indicate also that a close relation between DHP receptors and calcium channels must be taken with caution.
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