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  • Title: Evaluation of a new monoclonal radioimmunoassay system for carcinoembryonic antigen.
    Author: Matsuoka Y, Kuroki M, Okamoto N, Ikeda S, Hara Y, Minamizawa T, Tachibana S, Ogawa H, Tabata N.
    Journal: Jpn J Clin Oncol; 1988 Jun; 18(2):97-103. PubMed ID: 2454336.
    Abstract:
    A newly established monoclonal radioimmunoassay system (kit II) for carcinoembryonic antigen (CEA) was evaluated in comparison to a conventional polyclonal system (kit I). Among 619 unselected serum samples, approximately 15% were CEA positive with kit I, whereas 27% were positive with kit II; consequently, approximately 12% showed dissociated CEA values to be positive only with kit II. More than 75% of patients with the dissociated values were found to have a malignant disease. Positive rates in normal individuals (266 samples) were less than 5% with both the kit I and kit II and, in those with benign disease were 11.9% with kit II, except for liver cirrhosis in which a quite high positive rate (58%) was obtained. In contrast, a definitely increased positive rate in malignant disease (381 samples) was obtained with kit II (61.4%) in comparison to that with kit I (42.3%). The assessment of technical qualities, such as reproducibility, recovery and dilution tests, demonstrated the excellent performance of kit II.
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