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  • Title: Specific lysis by CD8+ T cells of Schwann cells expressing Mycobacterium leprae antigens.
    Author: Steinhoff U, Kaufmann SH.
    Journal: Eur J Immunol; 1988 Jun; 18(6):969-72. PubMed ID: 2454827.
    Abstract:
    In vitro cultured murine Schwann cells which were devoid of class I and class II gene products of the major histocompatibility complex expressed class I, though not class II, antigens after stimulation with recombinant interferon-gamma. Recombinant IFN-gamma-stimulated Schwann cells after priming with M. leprae were lysed by antigen-specific CD8+ T lymphocytes in vitro. These findings suggest that specific lysis of M. leprae-infected Schwann cells by CD8+ CTL plays a role in leprosy.
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