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  • Title: [Association of adiponectin gene polymorphisms +45T/G with gestational diabetes mellitus and neonate birth weight].
    Author: Li GH, Kong LJ, Zhang L, Zhang WY.
    Journal: Zhonghua Yi Xue Za Zhi; 2013 Dec 17; 93(47):3770-2. PubMed ID: 24548395.
    Abstract:
    OBJECTIVE: To determine the association of single-nucleotide polymorphisms (SNPs)+45T/G of adiponectin gene with gestational diabetes mellitus (GDM) and neonate birth weight. METHODS: A total of 264 GDM and 272 pregnant women with normal glucose (NG) were enrolled. DNA was successfully extracted from peripheral blood leucocyte samples. And SNPs+45T/G of adiponectin gene were examined. We also analyzed differences in the genotypic distribution and allelic frequencies in SNP+45T/G of adiponectin gene among GDM group with different neonate birth weights. RESULTS: There was no significant difference between two groups with respects to SNP +45T/G polymorphisms of adiponectin gene (P > 0.05). But significant genotypic difference existed in SNP+45T/G among three GDM groups with different birth weights. Frequencies of T allele were significantly higher in the GDM group with higher birth weight, 68.75% in GDM group with macrosomia and 72.86% in GDM group with 3000-4000 g birth weight (both P < 0.01). And there was no significant difference in SNP +45T/G polymorphisms of adiponectin gene between GDM women and NG group with macrosomia. CONCLUSION: SNP +45T/G polymorphisms of adiponectin gene are not associated with GDM. However, SNP+45T/G polymorphisms of adiponectin gene of GDM women are closely associated with neonate birth weigh. The G/T polymorphisms of SNP+45 of adiponectin are not obviously associated with a higher occurrence of macrosomia in GDM women.
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