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  • Title: Efficacy of scorpion antivenom plus prazosin versus prazosin alone for Mesobuthus tamulus scorpion sting envenomation in children: a randomised controlled trial.
    Author: Pandi K, Krishnamurthy S, Srinivasaraghavan R, Mahadevan S.
    Journal: Arch Dis Child; 2014 Jun; 99(6):575-80. PubMed ID: 24550184.
    Abstract:
    OBJECTIVE: To assess the efficacy of combined use of scorpion antivenom (SAV) with prazosin, compared with prazosin alone in children with Mesobuthus tamulus scorpion envenomation. STUDY DESIGN: Randomised controlled trial. SETTING: A tertiary care hospital in south India. PATIENTS: 50 children with definite history and/or systemic manifestations of scorpion envenomation were recruited from the paediatric emergency or outpatient department from February 2012 to July 2013. INTERVENTIONS: The children were randomised into two groups. In 25 children, SAV was administrated as a slow intravenous bolus combined with prazosin (group A). Others received prazosin alone (group B). Results were analysed by Student t test and χ(2) test. MAIN OUTCOME MEASURES: Time required for resolution of autonomic symptoms, total dose of prazosin, adverse events. RESULTS: Children in group A recovered earlier than those in group B (mean difference 9.1 h, 95% CI 6.0 to 12.2). 23 children (92%) in group A were clear of autonomic symptoms within 10 h, compared with 10 children (40%) in group B (mean difference 52%, 95% CI 29% to 75%). The proportion of children deteriorating to clinical grade 3 or 4 was 8% in group A as against 44% in group B (p<0.01). The mean dose of prazosin required was 54 µg/kg versus 130.8 µg/kg in group A and B, respectively (p<0.01). SAV was not associated with severe adverse reactions. CONCLUSIONS: Usage of SAV led to faster recovery and reduced the incidence of myocardial dysfunction. Combined therapy with SAV and prazosin is beneficial for children with M tamulus scorpion envenomation. TRIAL REGISTRATION NUMBER: CTRI/2013/09/004002 (Clinical Trials Registry of India).
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