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  • Title: Physiological and pharmacological correlates of calcium antagonist receptors.
    Author: Wagner JA, Reynolds IJ, Snyder SH.
    Journal: J Cardiovasc Pharmacol; 1987; 10 Suppl 10():S1-9. PubMed ID: 2455102.
    Abstract:
    We studied voltage-sensitive and Na-dependent Ca2+ flux into synaptosomes as well as Na-dependent influx in cardiac sarcolemmal vesicles. Rapid, voltage-sensitive 45Ca2+ influx into synaptosomes is blocked by cadmium (IC50 1 microM) and the novel peptide toxin omega-conotoxin GVIA (30% of uptake blocked by 50 pM toxin), but not by dihydropyridine and phenylalkylamine calcium antagonists, even though [3H]dihydropyridines and [3H]phenylalkylamines bind to synaptosomes. The toxin also blocks voltage-sensitive neurotransmitter release from synaptosomes. Sodium-dependent Ca2+ flux into synaptosomes and cardiac sarcolemmal vesicles is inhibited by selected antihistamines, neuroleptics, and tricyclic antidepressants. We can elicit neurotransmitter release from synaptosomes by changing the Na gradient; this neurotransmitter release is absolutely Ca2+-dependent and blocked by Na+/Ca2+ exchange inhibitors, thereby suggesting that physiological neurotransmitter release may have a Na+/Ca2+ exchange component. More potent Na+/Ca2+ exchange inhibitors may have cardiovascular roles as inotropic agents or antagonists of calcium-related injury to cardiomyocytes during reperfusion or other disease states.
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