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  • Title: Calcium channel blockade in dialysis patients with left ventricular hypertrophy and well-preserved systolic function.
    Author: Whelton PK, Watson AJ, Kone B, Fortuin NJ.
    Journal: J Cardiovasc Pharmacol; 1987; 10 Suppl 10():S185-6. PubMed ID: 2455129.
    Abstract:
    Echocardiographic evidence of left ventricular hypertrophy with well-preserved systolic function was established in 4 chronic hemodialysis patients with a history of refractory pulmonary congestion. In each patient a trial of treatment with verapamil (40 mg t.i.d.) resulted in symptomatic improvement, an increase in nadir intradialysis blood pressure, and a marked reduction in intradialytic symptomatic hypertensive episodes and the need for intravenous saline administration. These data suggest that (a) a subset of chronic hemodialysis patients with refractory congestive heart failure and dialysis-related hypotension have hypertrophic cardiomyopathy with well-preserved systolic function, and (b) such patients may derive greater benefit from verapamil treatment than from the more conventional approach to drug therapy with digoxin and nitrates.
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