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  • Title: Regression of cardiac hypertrophy after antihypertensive therapy with nifedipine and captopril.
    Author: Sheiban I, Arcaro G, Covi G, Accardi R, Zenorini C, Lechi A.
    Journal: J Cardiovasc Pharmacol; 1987; 10 Suppl 10():S187-91. PubMed ID: 2455130.
    Abstract:
    The effects of two antihypertensive agents, nifedipine (N) and captopril (C), on left ventricular (LV) mass and volume were studied in 16 patients with essential hypertension (8 treated with N and 8 with C for 6 months) by means of a complete M-mode echocardiogram monitored by two-dimensional echocardiography. Both N and C induced a significant reduction in end-diastolic, but not systolic, posterior wall and septum thickness and an increase in end-diastolic volume, but not in end-systolic volume. A significant increase in the contribution of rapid filling together with a simultaneous reduction in the contribution of atrial systole to end diastolic volume were also observed. The reduction in LV wall thickness and mass after both C and N might be attributed to an improvement in diastolic function and to a reduction in wall tension, rather than to an effective regression of LV hypertrophy.
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