These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of clonidine and nifedipine on left ventricular hypertrophy and muscle mass in hypertensive patients.
    Author: Kleine P, Meissner E, von Bruchhausen V, Brückner S.
    Journal: J Cardiovasc Pharmacol; 1987; 10 Suppl 12():S180-6. PubMed ID: 2455176.
    Abstract:
    In a parallel group randomized trial we compared the echocardiographically documented effects of clonidine (cl) versus nifedipine (nf) on left ventricular hypertrophy (LVH) and muscle mass (LVM) in hypertensive subjects. Twenty-one patients with concentric LVH (thickness of interventricular septum, IVS, and left posterior wall, LPW, above 11 mm) were given a 2D and M-mode echocardiogram before (pre) and 12 and 24 weeks, respectively, after therapy was initiated (mean oral cl dosage 150 micrograms; nf, 30 mg/day). At the end of the follow-up period in the cl group blood pressure declined by an average of 16/11 mm Hg compared with 30/20 mm Hg in the nf group (intergroup differences, NS). The thickness of the IVS decreased from a mean of 15.0 +/- 1.9 mm and 15.1 +/- 1.5 pre-therapy to 12.6 +/- 2.3 for cl (p = 0.0001) and 13.1 +/- 1.5 mm for nf (p = 0.001) after 24 weeks, respectively. This was similar to the regression of the LV posterior wall with 14.7 +/- 1.5 and 14.5 +/- 1.6 mm pre-therapy to 12.0 +/- 1.1 in the cl group (p = 0.0001) and 12.7 +/- 1.7 for nf (p = 0.006). As the internal LV-diameter were relatively constant over the treatment period, the calculated values for LVM dropped from a mean of 406.5 +/- 125.9 and 401.4 +/- 106.6 to 274.8 +/- 78.7 and 297.5 +/- 85.0 g, respectively, corresponding to -31.6 +/- 11.0% for cl (p = 0.0001) and -25.2 +/- 12.6% for nf (p = 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
    [Abstract] [Full Text] [Related] [New Search]