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  • Title: Drug-induced myotonia in human intercostal muscle.
    Author: Kwieciński H, Lehmann-Horn F, Rüdel R.
    Journal: Muscle Nerve; 1988 Jun; 11(6):576-81. PubMed ID: 2455224.
    Abstract:
    The myotonia-inducing effects of furosemide and clofibrate, two widely used pharmaceutical agents, were investigated in excised human external intercostal muscle. The effects of anthracene-9-carboxylic acid (9-AC), a well-known myotonia-producing chemical, were also tested for comparison. In the presence of these drugs the electrical threshold was lowered, and a constant current pulse produced multiple spiking. Short trains of direct stimuli were often followed by after-activity, and this caused a myotonia-like prolongation of muscle contraction. Voltage-clamp experiments showed that 0.05 mM anthracene-9-carboxylic acid, 1 mM furosemide, and 1 mM clofibrate decreased the chloride conductance of the muscle fiber membrane to 14, 18, and 40%, respectively, of the normal value, and the myotonia-inducing potency of the 3 drugs was correlated with the decreased chloride conductance. The potassium currents were not affected by these compounds.
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