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  • Title: Galanin impairs acquisition but not retrieval of spatial memory in rats studied in the Morris swim maze.
    Author: Sundström E, Archer T, Melander T, Hökfelt T.
    Journal: Neurosci Lett; 1988 Jun 07; 88(3):331-5. PubMed ID: 2455255.
    Abstract:
    The effect of intraventricular administration of the neuropeptide galanin on acquisition and retrieval in a modified Morris swim maze was studied in rats. Galanin induced a significant deficit in the acquisition of the task while no effects on the retrieval were observed. No deficits were seen 24 h after the last treatment. Galanin did not increase the number of failures to reach the platform. It is suggested that endogenous galanin modulates learning possibly via the galanin-containing cholinergic neurons in the septum-basal forebrain area projecting to the hippocampus and cortex.
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