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  • Title: The relative importance of Escherichia coli exonuclease III and endonuclease IV for the hydrolysis of 3'-phosphoglycolate ends in polydeoxynucleotides.
    Author: Siwek B, Bricteux-Grégoire S, Bailly V, Verly WG.
    Journal: Nucleic Acids Res; 1988 Jun 10; 16(11):5031-8. PubMed ID: 2455278.
    Abstract:
    In vitro, in the presence of Mg++, the 3'-phosphoglycolatase activity of endonuclease IV is about 4-times smaller than that of exonuclease III for the same AP endonuclease activity. It thus seems that endonuclease IV has only a minor role in the repair of strand breaks limited by 3'-phosphoglycolate ends in Escherichia coli even after the amount of enzyme has been increased by induction with O2 -generating agents.
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