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  • Title: Pd-catalyzed nucleophilic fluorination of aryl bromides.
    Author: Lee HG, Milner PJ, Buchwald SL.
    Journal: J Am Chem Soc; 2014 Mar 12; 136(10):3792-5. PubMed ID: 24559304.
    Abstract:
    On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction.
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