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  • Title: Histamine releasing action of calcium ionophore 985-I.
    Author: Gushchin IS, Zebrev AI, Voitenko VG.
    Journal: Agents Actions; 1988 Apr; 23(3-4):161-4. PubMed ID: 2455977.
    Abstract:
    The polyether antibiotic 985-I induced histamine release from rat and mouse mast cells and human basophils. Histamine release induced by low concentrations (10-50 microM) of the ionophore was a selective (noncytotoxic) process. It was energy and Ca2+-dependent and was potentiated by glucose. In this respect the mode of action of 985-I was similar to that of the Ca2+-ionophore A23187. On the other hand some pharmacological agents (phencarol, verapamil and amitriptyline) inhibited histamine secretion induced by 985-I but not A23187-induced histamine release. These data point to some differences between the mechanisms of action of 985-I and A23187.
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