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  • Title: Effect of stobadine on stimulated isolated mast cells.
    Author: Drábiková K, Pecivová J, Nosál R.
    Journal: Agents Actions; 1988 Apr; 23(3-4):188-90. PubMed ID: 2455985.
    Abstract:
    Stobadine, an antiarrhythmic drug with antihistaminic properties, did not liberate histamine from mast cells in vitro. Compound 48/80-stimulated histamine liberation and degranulation was decreased in the presence of stobadine in a dose-dependent way. The spontaneous as well as stimulated calcium displacement in mast cells was significantly decreased by stobadine. Stobadine most probably possesses a membrane-stabilizing effect on isolated rat mast cells.
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