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  • Title: Sclerouveitis associated with Rosai-Dorfman disease in an HIV-infected patient.
    Author: Monroe AK, Burkholder BM, Butler NJ, Duffield AS.
    Journal: Ocul Immunol Inflamm; 2014 Jun; 22(3):236-8. PubMed ID: 24564426.
    Abstract:
    PURPOSE: To describe a case of Rosai-Dorfman-associated sclerouveitis in an HIV-infected patient. DESIGN: Case report. METHODS: A 49-year-old man with HIV had bilateral eye pain, redness, photophobia, and multiple systemic complaints. He underwent serial ocular examinations, abdomen/pelvis CT scan, and lymph node biopsy. RESULTS: Ophthalmologic evaluation revealed bilateral, nongranulomatous anterior uveitis and anterior scleritis. Biopsy of a retroperitoneal lymph node identified on CT revealed mixed inflammatory infiltrate composed of histiocytes, lymphocytes, and plasma cells involving fibroadipose tissue, indicating Rosai-Dorfman disease. CONCLUSIONS: This is the first report of sclerouveitis in Rosai-Dorfman disease. Rosai-Dorfman is typically self-limiting, occurring rarely in HIV.
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