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  • Title: Primary mucinous adenocarcinoma of the renal pelvis with carcinoma in situ in the ureter.
    Author: Abbas M, Kramer MW, Spieker T, Herrman TR, Merseburger AS, Müller KM, Kuczyk MA, Becker JU, Kreipe HH.
    Journal: J Egypt Natl Canc Inst; 2014 Mar; 26(1):51-4. PubMed ID: 24565683.
    Abstract:
    Primary epithelial tumor of the renal pelvis is rare and only 100 cases are reported in the literature [1]. Histological examination of the tumor showed glands, cysts, and papillae lined by pseudostratified columnar epithelium with hyperchromatic nuclei. Scattered signet ring-type cells were also seen floating in large pools of extracellular mucin. Sections from the ureter showed a component of adenocarcinoma in situ. No invasive tumor was identified in ureteric tissue. One case was reported with carcinoma in situ of the ureter (2). Immunohistochemically: The tumor showed positivity for CK7, CK20, CK8/18, GATA-3, MSH-2, MSH-6, MLH-1, Ber-EP4, and S-100-P with focal positivity for CDX-2, weak positivity for PMS-2 and negativity in TTF-1 and Her-2. Molecular pathological analysis revealed microsatellite stability and without mutation in K-ras-gene. Thus, a diagnosis of mucinous adenocarcinoma of the renal pelvis with in situ adenocarcinoma of the ureter was made.
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