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  • Title: Cooperative enhancement of F-cell formation in baboons treated with erythropoietin and hydroxyurea.
    Author: Al-Khatti A, Papayannopoulou T, Knitter G, Fritsch EF, Stamatoyannopoulos G.
    Journal: Blood; 1988 Aug; 72(2):817-9. PubMed ID: 2456801.
    Abstract:
    Chronically anemic baboons on a continuous hydroxyurea regimen were treated with pulsed doses of recombinant human erythropoietin (rHuEpo) to test whether the combination of these two compounds, which individually induce F-cell production, can enhance further F-cell output. A low-F-cell-responding animal under chronic hydroxyurea treatment was given three separate pulses of Epo and responded with F-reticulocyte increments that were similar to the sum increments caused by either hydroxyurea alone or rHuEpo alone. The same results were obtained in a high-F-responding animal similarly treated. These findings suggest that rHuEpo and hydroxyurea can increase F cell numbers in an additive fashion. It is speculated that both compounds act through perturbation of erythroid differentiation kinetics.
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