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  • Title: Effect of vitamin D on postoperative adhesion formation in a rat uterine horn adhesion model.
    Author: Yilmaz SS, Hizli D, Yilmaz E, Eryilmaz OG, Hizli F, Haltaş H.
    Journal: J Reprod Med; 2013; 58(11-12):511-6. PubMed ID: 24568046.
    Abstract:
    OBJECTIVE: To determine the role of vitamin D for preventing or reducing postoperative adhesions. STUDY DESIGN: The uterine horn adhesion model was carried out in 24 female Wistar rats. The animals were randomized into 4 groups: (1) control, (2) Ringer's lactate, (3) olive oil, and (4) vitamin D. Adhesion grade and histologic findings of adhesion-carrying tissues were evaluated, and groups were compared according to these parameters. RESULTS: Rats treated with vitamin D had less adhesion and lower inflammation grade when compared to the control and Ringer's lactate groups, and the results were statistically significant (p < 0.05). On the other hand, no difference was detected between the groups according to the fibrosis score. CONCLUSION: Vitamin D decreased postsurgical adhesion scores by both visual scores and histologic analyses in a rat model. Further experimental and clinical trials are required to confirm these results.
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