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  • Title: Highly enantioselective organocatalyzed vinylogous Michael-type reaction for the construction of trifluoromethylated all-carbon quaternary stereocenters.
    Author: Chen Q, Wang G, Jiang X, Xu Z, Lin L, Wang R.
    Journal: Org Lett; 2014 Mar 07; 16(5):1394-7. PubMed ID: 24568696.
    Abstract:
    The first example of a highly enantioselective vinylogous Michael-type reaction of β,β-disubstituted nitroalkenes is disclosed. A series of biologically important chiral oxindoles, featuring a trifluoromethylated all-carbon quaternary chiral center, were obtained in good yields with excellent enantioselectivities (up to >99% ee).
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