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  • Title: Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: overview and application.
    Author: Yoshii Y, Furukawa T, Saga T, Fujibayashi Y.
    Journal: Cancer Lett; 2015 Jan 28; 356(2 Pt A):211-6. PubMed ID: 24569091.
    Abstract:
    Understanding cancer-specific metabolism is important for identifying novel targets for cancer diagnosis and therapy. Induced acetate/acetyl CoA metabolism is a notable feature that is related to fatty acid synthesis supporting tumor growth. In this review, we focused on the recent findings related to cancer acetate/acetyl CoA metabolism. We also introduce [1-¹¹C]acetate positron emission tomography (PET), which is a useful tool to visualize up-regulation of acetate/acetyl CoA metabolism in cancer, and discuss the utility of [1-¹¹C]acetate PET in cancer diagnosis and its application to personalized medicine.
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