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  • Title: Palmitoyl-CoA inhibits the mitochondrial inner membrane anion-conducting channel.
    Author: Halle-Smith SC, Murray AG, Selwyn MJ.
    Journal: FEBS Lett; 1988 Aug 15; 236(1):155-8. PubMed ID: 2456951.
    Abstract:
    Palmitoyl-CoA is shown here to inhibit the pH-dependent anion-conducting channel (IMAC) in the inner membrane of rat liver mitochondria, with half-maximal inhibition at 2.4 microM. It has little effect on the transport of ribose, thiocyanate and glutamate. Palmitic acid and palmitoyl-carnitine stimulate the entry of all the above metabolites. CoASH and carnitine have no effect on chloride uniport. Palmitoyl-CoA and the IMAC may have a role in controlling thermogenesis in liver mitochondria.
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