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  • Title: A preliminary report of increased plasma levels of IL-33 in bipolar disorder: further evidence of pro-inflammatory status.
    Author: Barbosa IG, Morato IB, de Miranda AS, Bauer ME, Soares JC, Teixeira AL.
    Journal: J Affect Disord; 2014 Mar; 157():41-4. PubMed ID: 24581826.
    Abstract:
    BACKGROUND: Recent findings suggest an important role for inflammation in the neurobiology of bipolar disorder (BD). Interleukin 33 (IL-33) is a cytokine with multiple functions and may act as a nuclear factor regulating transcription and as an "alarmin". IL-33 exerts part of its function through the receptor ST2 that also exists in a soluble form (sST2). This study was performed to evaluate IL-33 and sST2 plasma levels in BD patients. METHODS: We evaluated IL33 and sST2 plasma levels of 46 BD patients (23 in euthymia and 23 in mania) and 23 healthy controls using enzyme-linked immunosorbent assay (ELISA). BD patients were age and gender matched healthy controls. RESULTS: IL-33 levels were higher in BD patients (p=0.02) but there was no difference in sST2 (p=0.55). IL33 and sST2 plasma levels were not correlated with age, neither was influenced by clinical comorbidities nor medications in use. CONCLUSION: These findings corroborate the view of BD as a multisystem condition with a proinflammatory profile.
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