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  • Title: Reduction of voxel bleeding in highly accelerated parallel (1) H MRSI by direct control of the spatial response function.
    Author: Kirchner T, Fillmer A, Tsao J, Pruessmann KP, Henning A.
    Journal: Magn Reson Med; 2015 Feb; 73(2):469-80. PubMed ID: 24585512.
    Abstract:
    PURPOSE: To substantially improve spatial localization in magnetic resonance spectroscopic imaging (MRSI) accelerated by parallel imaging. This is important in order to make MRSI more reliable as a tool for clinical applications. METHODS: The sensitivity encoding acceleration technique with spatial overdiscretization is applied for the reconstruction of parallel MRSI. In addition, the spatial response function is optimized by minimizing its deviation from a previously chosen target function. This modified minimum-norm sensitivity encoding-MRSI reconstruction approach is applied in this article for in vivo pulse-acquire MRSI of human brain at 7T with simulated acceleration factors of 2, 4, and 9 as well as actual 4-fold accelerated MRSI. RESULTS: The sidelobes of the spatial response function are significantly suppressed, which reduces far-reaching voxel bleeding. At the same time, the major enlargement of the effective voxel size, which would be introduced by conventional k-space apodization methods, is largely avoided. Regularization allows for a practical trade-off between noise minimization, effective voxel size, and unaliasing. Although not aiming at increasing the nominal spatial resolution, a better spatial specificity is achieved. CONCLUSION: Simultaneous suppression of short- and far-reaching voxel bleeding in MRSI is analyzed and reconstruction of highly accelerated parallel in vivo MRSI is demonstrated.
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