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  • Title: [The channel function of the hydrophobic fragment of Ca ATPase in the sarcoplasmic reticulum of rabbit skeletal muscles in the early period after x-ray radiation exposure].
    Author: Voĭtskiĭ VM, Fedorov AN, Kucherenko NE, Kurskiĭ MD, Khizhniak SV.
    Journal: Radiobiologiia; 1988; 28(4):450-4. PubMed ID: 2458608.
    Abstract:
    At early times (1 and 24 h) following local single exposure of rabbit hindlimbs to 0.21 C/kg X-radiation Ca ATPase was isolated from sarcoplasmic reticulum of skeletal muscles and inserted in liposomes the treatment of which with trypsin resulted in the formation of proteoliposomes with a Ca ATPase hydrophobic fragment (Mr 45-50 kDa). It was shown that X-radiation increased the permeability of univalent and bivalent cations through a channel formed by the hydrophobic fragment of Ca ATPase and diminished ion selectivity of this channel.
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