These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Copper-catalyzed site-selective intramolecular amidation of unactivated C(sp³)-H bonds.
    Author: Wu X, Zhao Y, Zhang G, Ge H.
    Journal: Angew Chem Int Ed Engl; 2014 Apr 01; 53(14):3706-10. PubMed ID: 24590659.
    Abstract:
    The intramolecular dehydrogenative amidation of aliphatic amides, directed by a bidentate ligand, was developed using a copper-catalyzed sp(3) C-H bond functionalization process. The reaction favors predominantly the C-H bonds of β-methyl groups over the unactivated methylene C-H bonds. Moreover, a preference for activating sp(3) C-H bonds of β-methyl groups, via a five-membered ring intermediate, over the aromatic sp(2) C-H bonds was also observed in the cyclometalation step. Additionally, sp(3) C-H bonds of unactivated secondary sp(3) C-H bonds could be functionalized by favoring the ring carbon atoms over the linear carbon atoms.
    [Abstract] [Full Text] [Related] [New Search]