These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Differential mechanisms of action of the novel γ-aminobutyric acid receptor antagonist ectoparasiticides fluralaner (A1443) and fipronil.
    Author: Asahi M, Kobayashi M, Matsui H, Nakahira K.
    Journal: Pest Manag Sci; 2015 Jan; 71(1):91-5. PubMed ID: 24591229.
    Abstract:
    BACKGROUND: Fluralaner (A1443) is an isoxazoline ectoparasiticide that is a novel antagonist of γ-aminobutyric acid (GABA) receptors (GABARs), with a potency comparable to that of fipronil, a phenylpyrazole ectoparasiticide. To clarify the biological effectiveness of fluralaner against fipronil-resistant pests, differences in the actions of fluralaner and fipronil on GABARs that possess resistance to dieldrin (rdl)-type mutations were evaluated. RESULTS: Fipronil had neither pest control nor GABAR-antagonistic activities against two-spotted spider mites (Tetranychus urticae) that had two different rdl-type amino acids (A(301) → H and T(350) → A: Drosophila melanogaster GABAR numbering) and against small brown planthoppers (Laodelphax striatellus) that had a novel rdl-type (A(283) → N) mutation in GABARs. In contrast, fluralaner showed not only high pest control activities against these pests, but also excellent antagonistic activities for these rdl-type GABARs. CONCLUSION: The findings indicate that rdl-type fipronil-resistant pests do not show cross-resistance to fluralaner owing to the differential actions of fluralaner and fipronil on the GABAR.
    [Abstract] [Full Text] [Related] [New Search]