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  • Title: Cytotoxic polycyclic polyprenylated acylphloroglucinols from Hypericum attenuatum.
    Author: Zhou ZB, Zhang YM, Pan K, Luo JG, Kong LY.
    Journal: Fitoterapia; 2014 Jun; 95():1-7. PubMed ID: 24603092.
    Abstract:
    Six new polycyclic polyprenylated acylphloroglucinols, attenuatumiones A-F (1-6), together with twelve known analogs (7-18) were isolated from the whole plant of Hypericum attenuatum. Their structures were elucidated by spectroscopic methods, and the absolute configuration of C-13 in attenuatumione C (3) was deduced via the circular dichroism datum of the in situ formed [Rh2(OCOCF3)4] complexes. All isolates were evaluated for the cytotoxic activities on three human cancer cell lines. Compound 3 showed moderate cytotoxic activities with IC50 values of 10.12 and 10.56 μM against SMMC7721 and U2OS, respectively.
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