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  • Title: [Abortion in the early stage of pregnancy and prostaglandin].
    Author: Shimada N.
    Journal: Josanpu Zasshi; 1978 Jan; 32(1):53. PubMed ID: 246048.
    Abstract:
    Spontaneous abortion in the early stage of pregnancy is now linked to increased prostaglandin (PG) in blood. It has been known for some time that pregnant women's blood content of PG increases at the onset of labor. PGE2 and PGF2alpha have been used to induce labor during the last trimester. Lately PG is sometimes used to induce artificial abortion during the 2nd trimester. According to a study conducted by Dr. Kunimoto of Iwate School of Medicine, there is correlation between greatly increased PG and cramps felt by spontaneous abortion candidates during the 1st trimester. Theoretically, therefore, it is possible to prevent miscarriages in the early stage by administering antagonistic medication such as indomethacin. The antagonistic effect of indomethacin is confirmed but its side effect on the circulatory organs of the fetus still needs to be investigated.
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