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  • Title: Focal encephalitis following varicella-zoster virus reactivation without rash in a healthy immunized young adult.
    Author: Halling G, Giannini C, Britton JW, Lee RW, Watson RE, Terrell CL, Parney IF, Buckingham EM, Carpenter JE, Grose C.
    Journal: J Infect Dis; 2014 Sep 01; 210(5):713-6. PubMed ID: 24604820.
    Abstract:
    Herein we describe an episode of focal varicella-zoster virus (VZV) encephalitis in a healthy young man with neither rash nor radicular pain. The symptoms began with headaches and seizures, after which magnetic resonance imaging detected a single hyperintense lesion in the left temporal lobe. Because of the provisional diagnosis of a brain tumor, the lesion was excised and submitted for pathological examination. No tumor was found. But the tissue immunostained positively for VZV antigens, and wild-type VZV sequences were detected. In short, this case represents VZV reactivation, most likely in the trigeminal ganglion, in the absence of clinical herpes zoster.
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