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  • Title: Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities.
    Author: Ramli RA, Lie W, Pyne SG.
    Journal: J Nat Prod; 2014 Apr 25; 77(4):894-901. PubMed ID: 24606395.
    Abstract:
    Four new stichoneurine-type alkaloids, stichoneurines F and G (1-2) and sessilistemonamines E and F (3-4), have been isolated from the root extracts of Stichoneuron caudatum. The structures and relative configurations of these alkaloids have been determined by spectroscopic methods and molecular modeling experiments. Compounds 1-4 were tested for their acetylcholinesterase (AChE) inhibitory activities against human AChE. Compound 3 showed significant inhibitory activity with an IC50 value of 9.1±0.15 μM.
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