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  • Title: Antigenic structure of surface-exposed regions of the major outer-membrane protein of Chlamydia trachomatis.
    Author: Newhall WJ.
    Journal: Rev Infect Dis; 1988; 10 Suppl 2():S386-90. PubMed ID: 2460912.
    Abstract:
    The major outer-membrane protein (MOMP) of Chlamydia trachomatis displays a number of surface-exposed epitopes. Some of these are shared by all or some of the 15 known serovars, whereas others are serovar-specific. With use of epitope-mapping analysis of limited proteolytic digests of purified MOMPs with monoclonal antibodies, the present study assessed whether the same or different surface-exposed regions of the protein express these different epitopes. Results with both chymotrypsin and the staphylococcal V8 protease for MOMP of serovar F indicated that many of the shared surface epitopes are clustered in one region whereas the serovar-reactive epitope is located in a separate region. Analysis of MOMPs from all the serovars with a species-specific monoclonal antibody indicated that each MOMP possesses a structurally analogous region that expresses this epitope. Such a region might play a role in pathogenic mechanisms that are shared by all serovars.
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