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  • Title: Interferon alters intracellular transport of vesicular stomatitis virus glycoprotein.
    Author: Singh VK, Maheshwari RK, Damewood GP, Stephensen CB, Oliver C, Friedman RM.
    Journal: J Biol Regul Homeost Agents; 1988; 2(2):53-62. PubMed ID: 2461053.
    Abstract:
    Double-label immunofluorescence staining studies in virus-infected subclone 11 of LB cells indicated that almost all of the vesicular stomatitis virus (VSV) glycoprotein (G) was plasma membrane-associated during the logarithmic phase of virus replication. In contrast, treatment with interferon (IFN) resulted in inhibition of VSV-G transport, so that almost all of the G remained associated with the Golgi complex (GC) at comparable times after infection. In both IFN-treated and control cells, G was resistant to treatment with the enzyme endo-beta-N-acetylglucosamine H (endo H) indicating that the bulk of the G had reached the trans compartment of the GC.
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