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  • Title: Direct coupling of a G-protein to dihydropyridine binding sites.
    Author: Bergamaschi S, Govoni S, Cominetti P, Parenti M, Trabucchi M.
    Journal: Biochem Biophys Res Commun; 1988 Nov 15; 156(3):1279-86. PubMed ID: 2461198.
    Abstract:
    Electrophysiological data support the existence of GTP-binding proteins interacting with voltage dependent calcium channels. Along this line the present study investigates the effect of GMP-PNP, a stable GTP analogue, on the displacement of [3H]-PN 200-110 binding by agonist and antagonist dihydropyridines in synaptic membranes prepared from rat cortex. The results show that GMP-PNP increases the ability of the agonist dihydropyridine BAY K 8644 to displace [3H]-PN 200-110 binding. The in vivo treatment with Pertussis Toxin abolishes the effect produced by the non-hydrolysable GTP analogue.
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