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  • Title: Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr.
    Author: Huang SZ, Zhang X, Ma QY, Peng H, Zheng YT, Hu JM, Dai HF, Zhou J, Zhao YX.
    Journal: Fitoterapia; 2014 Jun; 95():34-41. PubMed ID: 24613801.
    Abstract:
    Three tigliane-type diterpenoids named excoecafolins A-C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerifolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 μM, SI >1,836.9, 431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates.
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