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  • Title: Promising coagulation factor VIII bypassing strategies for patients with haemophilia A.
    Author: Duan X, Tang M, Zhang J, Yu H, Xu R.
    Journal: Blood Coagul Fibrinolysis; 2014 Sep; 25(6):539-52. PubMed ID: 24614429.
    Abstract:
    Haemophilia A is an X-linked recessive monogenic hereditary bleeding disorder caused by a deficiency or functional defect in coagulation factor VIII (FVIII). Typically, only 30% haemophilia A patients are treated with FVIII-specific products successfully. Therefore, other promising clotting factors and FVIII-bypassing factors exhibiting sufficient FVIII-independent activity, low immunogenicity and prolonged half-life are needed to conquer this malady. Here, we will systematically review the current status of the diverse FVIII-bypassing factors for the treatment of FVIII-insensitive haemophilia A patients.
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