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  • Title: [Antigenic properties of synthetic fragments of the heavy chain of influenza virus A hemagglutinin].
    Author: Samukov VV, Mazurkova NA, Kalashnikov VV, Ofitserov VI, Shval'e AF.
    Journal: Mol Gen Mikrobiol Virusol; 1988 Jul; (7):35-9. PubMed ID: 2461511.
    Abstract:
    The antigenic properties of the synthetic peptides corresponding to the regions 122-133, 136-147, 154-164 of the virus A/Aichi/2/68 hemagglutinin heavy chain have been studied. The 122-133 and 136-147 peptides comprise together almost whole antigenic determinant A, while the 154-164 peptide is a part of determinant B. Rabbits immunized by the peptides conjugated with carrier-protein BSA gave the high immune response to hapten-peptides. Each antiserum reacted only with homologous conjugate. All the antipeptide serums reacted with the virus A/Aichi/2/68 fixed on the base. Conjugate of the 136-147 peptide reacted with the rabbit antiserum against the virus A/Aichi/2/68 rendering the direct evidence to location of at least one hemagglutinin antigenic determinant in the region 136-147.
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