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  • Title: A tetrazole-based fluorescence "turn-on" sensor for Al(III) and Zn(II) ions and its application in bioimaging.
    Author: Ding WH, Cao W, Zheng XJ, Ding WJ, Qiao JP, Jin LP.
    Journal: Dalton Trans; 2014 May 07; 43(17):6429-35. PubMed ID: 24615141.
    Abstract:
    A tetrazole derivative 1-[(1H-tetrazol-5-ylimino)methyl]naphthalen-2-ol (H2L) as a fluorescent chemosensor for Al(3+) in DMSO and Zn(2+) in DMF was designed and synthesized. From (1)H NMR data, the Job plot and the ESI-MS spectrum, 1 : 1 stoichiometric complexation between H2L and Al(3+)/Zn(2+) was found in DMSO and DMF, respectively. The theoretical calculations at the level of B3LYP/6-311G** for the ground state and TD-B3LYP/6-311G** for the excited state revealed the sensing mechanism is the inhibition of excited state intramolecular proton transfer (ESIPT). And the possible fluorescent species formed in the DMSO and DMF solutions were deduced to be [Al(HL)(OH)(NO3)(H2O)(DMSO)] and [Zn(HL)(OH)(H2O)(DMF)]. What's more, it is confirmed that H2L could be used to detect Al(3+) and Zn(2+) in cells by bioimaging.
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