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  • Title: A one-pot O-phosphinative Passerini/Pudovik reaction: efficient synthesis of highly functionalized α-(phosphinyloxy)amide derivatives.
    Author: Soeta T, Matsuzaki S, Ukaji Y.
    Journal: Chemistry; 2014 Apr 22; 20(17):5007-12. PubMed ID: 24615915.
    Abstract:
    A one-pot O-phosphinative Passerini/Pudovik reaction has been developed, based on reacting aldehydes, isocyanides, and phosphinic acids followed by the addition of second aldehydes to form the corresponding α-(phosphinyloxy)amide derivatives. This is the first reported instance of a Passerini-type, isocyanide-based multicomponent reaction using a phosphinic acid instead of a carboxylic acid. The nucleophilicity of the phosphinate group allows a subsequent catalytic Pudovik-type reaction, affording the highly functionalized α-(phosphinyloxy)amide derivative in high yield. A wide range of aldehydes and isocyanides are applicable to this reaction.
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