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  • Title: Ionic currents in avian granulosa cells.
    Author: Schwartz JL, Mealing GA, Asem EK, Whitfield JF, Tsang BK.
    Journal: FEBS Lett; 1988 Dec 05; 241(1-2):169-72. PubMed ID: 2461875.
    Abstract:
    Transmembrane ionic currents have been recorded in single granulosa cells from the laying hen using the whole-cell patch-clamp technique. Under voltage-clamp conditions, depolarizing voltage steps evoked currents composed of a fast inactivating inward component and a delayed outward component. The former was activated at voltages more positive than -50 mV and was fully inactivated within 500 ms. It was blocked by D600 (methoxyverapamil) and by cobalt, suggesting that it is a calcium current. The latter displayed inward rectification and did not inactivate during long duration pulses. It was blocked by tetraethylammonium indicating that it is a potassium current. This is the first evidence of the existence of potassium and calcium transmembrane currents in granulosa cells.
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