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  • Title: Steady-state functional MRI using spoiled small-tip fast recovery imaging.
    Author: Sun H, Fessler JA, Noll DC, Nielsen JF.
    Journal: Magn Reson Med; 2015 Feb; 73(2):536-43. PubMed ID: 24619593.
    Abstract:
    PURPOSE: To determine whether a recently proposed steady-state magnetic resonance imaging (MRI) sequence, "small-tip fast recovery" (STFR), can be used for functional brain imaging. Compared to existing functional MRI (fMRI) based on T2*-contrast and long echo time, STFR has the potential for high-resolution imaging with reduced B0 artifacts such as geometric distortions, blurring, or local signal dropout. METHODS: We used Monte Carlo Bloch simulations to calculate the voxel-averaged steady-state signal during rest and activation, for blood oxygen level dependent (BOLD) and STFR. STFR relies on a tailored "tip-up" radiofrequency pulse to align the spins with the longitudinal axis after each data readout segment, and here we performed proof-of-concept in vivo STFR fMRI experiments using a tip-up pulse tailored to a two-dimensional region-of-interest in motor cortex. Experiments were performed on multiple subjects to test reliability of the functional activation maps. RESULTS: Bloch simulations predict a detectable functional signal that depends mainly on intravoxel dephasing, and only weakly on spin diffusion. STFR produces similar activation maps and signal change as BOLD in finger-tapping experiments, and shows reliability comparable to BOLD. CONCLUSION: STFR can produce functional contrast (even with short TE), and is a potential alternative to long-TE ( T2*) fMRI. The functional contrast arises primarily from the interaction between T2*-like dephasing and the tailored tip-up pulse, and not from spin diffusion.
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