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  • Title: Phototoxic dermatoses in pediatric BMT patients receiving voriconazole.
    Author: Goyal RK, Gehris RP, Howrie D, Cogley KM, Windreich RM, Venkataramanan R.
    Journal: Pediatr Blood Cancer; 2014 Jul; 61(7):1325-8. PubMed ID: 24619922.
    Abstract:
    We investigated the incidence of phototoxic skin reactions in pediatric BMT recipients treated with voriconazole. Nine out of 40 patients (22.5%), all Caucasian, developed skin lesions in sun-exposed distributions. Dermatologic findings included sunburn-like erythema, pseudo-porphyria, linear papulovesicular lesions, severe erosive cheilitis, dermatoheliosis and lentigines. Patients were treated with sun avoidance, high-potency sunscreens, and topical steroids with significant improvement in all cases. Prolonged voriconazole use requires close monitoring for chronic skin toxicities. Long-term risks including the risk of skin cancer need to be investigated.
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