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  • Title: A case of irreversible leukoencephalopathy in a patient with C virus hepatitis treated with pegylated interferon-alpha-2b and ribavirin.
    Author: Iacob SA, Petrescu AM, Iacob DG.
    Journal: Rom J Intern Med; 2013; 51(3-4):197-200. PubMed ID: 24620633.
    Abstract:
    We describe the case of a patient with C chronic hepatitis and early virological response on pegylated-interferon-alpha based therapy who presented clinical manifestations and magnetic resonance imaging suggestive for toxic leukoencephalopathy after 5 months of treatment. The negative results for neurotropic infectious agents and autoimmune markers opened the discussion of toxic interferon-induced leukoencephalopathy as a rare, but threatening neurologic side effect of this therapy.
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